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Quit using DEPAKOTE, and get in touch with your Health care service provider or get health care help straight away in case you acquire any of such indications of the intense pores and skin response: fever
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are allergic to divalproex sodium, valproic acid, sodium valproate, or any from the elements in Depakote. See the conclusion of this Medication Tutorial for a complete listing of components in Depakote.
are allergic to divalproex sodium, valproic acid, sodium valproate, or any on the components in Depakote. See the stop of the Medication Guidebook for an entire list of elements in Depakote. Have got a genetic dilemma called a urea cycle problem.
Mutagenesis Valproate was not mutagenic within an in vitro bacterial assay (Ames test), did not develop dominant lethal effects in mice, and did not maximize chromosome aberration frequency in an in vivo cytogenetic analyze in rats.
If you are taking Depakote throughout pregnancy for just about any health care affliction, your son or daughter is in danger for owning lessen IQ and may be in danger for developing autism or attention deficit/hyperactivity disorder.
You'll be able more info to inquire your pharmacist or healthcare supplier for information regarding Depakote that may be created for wellness pros.
Severe pores and skin reactions (for example Stevens-Johnson syndrome and toxic epidermal necrolysis) are noted with concomitant lamotrigine and valproate administration. See lamotrigine offer insert for specifics on lamotrigine dosing with concomitant valproate administration.
Dose reductions or discontinuation of valproate should be viewed as in sufferers with decreased foodstuff or fluid intake As well as in patients with abnormal somnolence. The ultimate therapeutic dose really should be attained on The premise of the two tolerability and scientific response [see WARNINGS AND Safeguards, Use In Specific Populations, and Medical PHARMACOLOGY].
Conditions of lifetime-threatening pancreatitis are already noted in both of those little ones and Grownups acquiring valproate. Many of the circumstances happen to be called hemorrhagic using a rapid progression from Original indicators to death. Scenarios happen to be described shortly immediately after Preliminary use as well as just after numerous decades of use.
On the other hand, since valproate may possibly connect with these or other concurrently administered AEDs in addition to other medications, periodic plasma focus determinations of concomitant AEDs are recommended through the early study course of therapy [see DRUG INTERACTIONS].
Patients with Mitochondrial Disease: There's an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes brought on by DNA mutations from the mitochondrial DNA Polymerase γ (POLG) gene (e.g. Alpers Huttenlocher Syndrome). Depakote is contraindicated in patients known to have mitochondrial Diseases because of POLG mutations and youngsters less than two decades of age who are clinically suspected of getting a mitochondrial ailment [see Contraindications (4)].
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